Metaplasticity in human primary somatosensory cortex: effects on physiology and tactile perception

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Metaplasticity in human primary somatosensory cortex: effects on physiology and tactile perception.

Theta-burst stimulation (TBS) over human primary motor cortex evokes plasticity and metaplasticity, the latter contributing to the homeostatic balance of excitation and inhibition. Our knowledge of TBS-induced effects on primary somatosensory cortex (SI) is limited, and it is unknown whether TBS induces metaplasticity within human SI. Sixteen right-handed participants (6 females, mean age 23 yr...

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Theta Burst Stimulation-induced Metaplasticity: Changing Tactile Perception and Physiology in Primary Somatosensory Cortex

I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public iii ABSTRACT Theta-burst stimulation (TBS) over human primary motor cortex evokes plasticity and metaplasticity, the latter contributing to the homeostatic...

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Homeostatic Metaplasticity in the Human Somatosensory Cortex

Long-term potentiation (LTP) and long-term depression (LTD) are regulated by homeostatic control mechanisms to maintain synaptic strength in a physiological range. Although homeostatic metaplasticity has been demonstrated in the human motor cortex, little is known to which extent it operates in other cortical areas and how it links to behavior. Here we tested homeostatic interactions between tw...

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Gamma Oscillations in Human Primary Somatosensory Cortex Reflect Pain Perception

Successful behavior requires selection and preferred processing of relevant sensory information. The cortical representation of relevant sensory information has been related to neuronal oscillations in the gamma frequency band. Pain is of invariably high behavioral relevance and, thus, nociceptive stimuli receive preferred processing. Here, by using magnetoencephalography, we show that selectiv...

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Continuous theta-burst rTMS over primary somatosensory cortex modulates tactile perception on the hand.

OBJECTIVE Theta-burst stimulation (TBS) over the primary somatosensory cortex (SI) alters cortical excitability, and in its intermittent form (iTBS) improves tactile spatial acuity. The effects of continuous TBS (cTBS) on tactile acuity remain unknown. The present study examined the influence of cTBS over SI on temporal and spatial tactile acuity on the contralateral hand. METHODS In separate...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2016

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00630.2015